As a result of the studies, it was determined that the drug called metolazone, which has been used clinically for therapeutic purposes for about 50 years, has a significant effect on the hsp-6 gene.
Osaka City University researchers found that the drug, which has been used in the treatment of hypertension (high blood pressure) for nearly 50 years, called metolazone, activates the cellular repair mechanisms in roundworms, increasing the overall life of the worms. It is aimed to adapt and examine the new research to humans.
When mitochondria, which are the organelles responsible for energy production in the cell, are damaged, the so-called mitochondrial unfolded protein response (UPRmt) can occur, and as a result, various repair mechanisms come into play. Some researchers think that this situation can be triggered by various drugs and thus the life span of the organism can be extended.
Although aging is a physiological process, it is suggested that some drugs can slow down aging and alleviate the negative effects of aging.
Human liver structure was created using Avatar Algae.
Osaka City University researchers first started by looking for any drug that could trigger the process called UPRmt, and they studied 3,000 drugs that could trigger gene activity called hsp-6 in genetically modified worms. It is stated that the aforementioned gene is intensely expressed in the UPRmt process.
As a result of the studies, it was determined that the drug called metolazone, which has been used clinically for therapeutic (therapeutic) purposes for about 50 years, was found to be significantly effective on the hsp-6 gene, and the aforementioned drug was tested on C. elegans worms.
As a result of the studies, it was determined that the mentioned drug significantly prolonged the life of round worms, but it was observed that the aforementioned effect was not observed in worms whose genes playing a role in UPRmt activity were inhibited (suppressed), in other words, this effect of metolazone was due to the activation of specific (specific) mitochondrial repair processes. The idea was supported. In addition, scientists also studied the aforementioned drug on human cell lines and it was observed that the aforementioned drug increased gene expression in mammals.
The new research has been published in the journal Biogerontology.