In order for the developed particles to show selective action to tumor cells, the particles with amorphous structure were covered with a lipid layer with pores. Thus, selectivity was achieved.
Nowadays, cancer treatments have gained momentum and although many drugs have been developed for cancer treatment, drugs can also harm healthy cells. Now, Ludwid Maximillian University of Munich (LMU) researchers have developed nanoparticles that selectively release the drugs in the tumor tissue.
In order for the developed particles to show selective action to tumor cells, the particles with amorphous structure were covered with a lipid layer with pores. In this way, it is stated that the particles will be absorbed by tumor cells without stimulating the immune (immune) system.
It is suggested that when the developed particles are taken into the cell, the lipid layer inside is destroyed and the drug load rich in calcium and citrate is released to the relevant cell, thus cancer cells are directly eliminated and killed.
The developed particles were tested in the laboratory environment and were tested on pleural (pleural) cancers that are very aggressive in mice. According to the studies, it is stated that the new method reduces tumor size by 40% to 60%, but it is not yet certain that the new method does not cause toxicity in healthy cells at the moment due to the mechanisms. Scientists continue their studies on this subject.